For 25 years now, Gavi, the Vaccine Alliance has helped build a safer, healthier, more equitable world. With the support of governments, civil society, and communities, Gavi has helped immunize over 1.1 billion childrenover just a few short decades — protecting an entire generation against life-threatening, infectious diseases.
But Gavi’s impact can’t be measured solely by immunization rates and lives saved. Vaccines don’t just save lives — they unlock economic livelihoods and futures. When children are protected from deadly infections, they’re more likely to attend school, grow into healthy adults, and contribute to robust societies and economies. Since its founding in 2000, Gavi’s work has generated an estimated $250 billion in economic benefits— a powerful return on a public health investment.
Now, as the world faces rising threats — from disease outbreaks and climate shocks to rising income inequality worldwide — Gavi is preparing for its most ambitious chapter yet.
A New Goal: 500 Million Children Protected by 2030
Through its 6.0 replenishment campaign, Gavi is calling on world leaders and partners to help raise new donor funding that will enable Gavi to reach another 500 million children by 2030, which could prevent over 8 million deaths and generate $100 billion in additional economic impact across 57 countries, primarily in the Global South.
This is so much more than a global health initiative — it’s a blueprint for building resilient communities, thriving economies, and a more equal future for all of us.
Vaccines Are a Global Safety Net
Adan Abdirahman Mohamed carries the cooler for vaccines as he leaves READO facility following a day of vaccinations in Baidoa, Somalia, September 2024. Adan's work is a part of Reach Zero Dose Children campaign, aimed at vaccinating children who have not received any vaccines, or missed communities by healthcare systems.
Vaccine equity is a cornerstone of global security in an interconnected world. Gavi plays a critical role in pandemic preparedness and response, helping countries strengthen routine immunization systems while responding to emerging threats. From COVID-19 to Ebola to cholera, Gavi’s model has proven nimble, sustainable, and effective — one that offers a boost rather than a handout to the countries it serves.
Gavi partners with countries to buy vaccines in bulk, reducing vaccine costs and enabling manufacturers to access new markets that might otherwise be considered too risky. By investing in long-term infrastructure, scaling innovation, and collaborating across borders, Gavi helps countries stand on their own. And in a world where the next pandemic is a matter of when — not if — that help is more vital than ever.
What’s at Stake
The challenges ahead to secure global health for all are real:
- In 2023, 14.5 million children still received zero doses of basic vaccines, leaving them vulnerable to a host of deadly diseases and infections.
- Adolescent girls in many low-income countries remain unprotected against HPV, a leading cause of cancer deaths worldwide.
- Malaria continues to kill nearly half a million children annually, despite the availability of new innovative vaccines.
- Climate change is exacerbating disease spread, overwhelming weak health systems that are already fragile to begin with.
But the opportunity we have before us is just as profound. With bold funding and support, Gavi could immunize half a billion more children over the next five years, helping eliminate deadly diseases and lay the groundwork for the world’s next great leap forward in health.
A Track Record of Impact
Bangladesh receives its first shipment of COVID-19 vaccines from the COVAX Facility led by directed by Gavi, CEPI, WHO and UNICEF in May 2021.
Since its founding, Gavi has helped deliver nearly 2 billion vaccine doses across 146 countries. These efforts have contributed to the aversion of more than 2.7 million deaths, proving the life-saving impact of immunization at scale.
During the COVID-19 pandemic, Gavi enabled access to 10 different vaccine products in low-income countries. Through strong partnerships and supply chain coordination, over $12 billion was mobilized to support vaccine equity — ensuring protection reached even the most underserved populations.
Beyond disease prevention, Gavi’s impact stretches into education, economic development, gender equity, and more. It’s easy to see why. When children stay healthy, they can stay in school. Parents end up spending less on health emergencies. Communities and societies can’t help but grow stronger.
Real Stories, Real Change
Young women are pictured during a national HPV vaccination campaign targeting over 1.6 million girls aged 10-15 in Nepal. Supported by GAVI, the campaign mobilizes thousands of health workers to administer vaccines across the nation.
Gavi’s work comes to life best through real-life stories. In Liberia, a mother named Mery Onumah walked hours to a rural clinic in Rivercess County to ensure her child received the new malaria vaccine. Thanks to Gavi’s partnership with the Ministry of Health, World Health Organization (WHO), and UNICEF, that vaccine is now part of the country’s routine immunization schedule, meaning it’s regularly available for all. In just a few months, over 45,000 children in high-burden, hard-to-reach regions have received this life-saving shot.
In Tanzania, a nationwide HPV vaccination campaign reached 97% of its 5-million-girl target — a staggering feat that could change the course of cervical cancer in the country. Backed by Gavi and informed by local research, the government switched to a single-dose HPV vaccine. This shift made the program more efficient, especially post-COVID. On the ground, community health workers like Chuma Bakari walked door-to-door, building trust, answering questions, and ensuring every girl, such as 11-year-old Lisa Peter, had a chance to be protected.
These are not isolated success stories. They represent what’s inevitable when global funding meets local leadership, and when innovation is made equitable and accessible to all.
How Global Citizens Are Taking Action
Global Citizen has already partnered with Gavi in the past to strengthen its push for vaccine equity. Since 2019, Global Citizens have taken over 1 million actions to support Gavi and their work to save children’s lives.
During Gavi’s last replenishment campaign, Global Citizen played a pivotal role in rallying international support by mobilizing public pressure and engaging directly with world leaders, communicating just how important it was to get behind Gavi.
Reflecting on this partnership, Dr. Seth Berkley, former CEO of Gavi, the Vaccine Alliance, told Global Citizen: "I am incredibly grateful to the thousands of Global Citizens who have supported Gavi’s mission to save lives and protect people’s health, especially as the world grapples with the impact of the COVID-19 pandemic. Their collective action through inspiring initiatives like Together at Home has helped secure essential funding to prevent diseases, protect the next generation with vaccines, and ensure global health security."
The last Gavi replenishment cycle showed the world what’s possible when countries step up. In the lead-up to the pledging conference in 2021, over 350,000 actions were taken by Global Citizens as part of our Defeat Disease Together Campaign. These efforts helped drive nearly $3.5 billion in commitments — nearly 40% of the funding Gavi received that cycle — including pledges from the US, the EU, Germany, Japan, and the UK.
Overall, the 2020–2021 replenishment campaign secured over $8.8 billion, thanks to both a groundswell of public support and high-level political leadership, including:
- The European Commission contributed €300 million. President Ursula von der Leyen made it clear where the body stood, stating, “Vaccination is a universal human right.”
- Australia, responding to more than 116,000 Global Citizen actions urging the government to step up for vaccine equity, pledged $300 million AUD, helping expand immunization across the Indo-Pacific.
- The UK pledged £1.65 billion — the largest commitment Gavi received that year — cementing its legacy as a global health leader. Hosting the replenishment summit, this show of support echoed its status as one of Gavi’s original founding donors. As then-Prime Minister Boris Johnson put it: “Together, we rise to fulfill the greatest shared endeavor of our lifetime — the triumph of humanity over disease, now and for the generations that follow.”
World leaders gather in Brussels on June 25, 2025 for Gavi, the Vaccine Alliance's replenishment event, held in partnership with Global Citizen. | Image: Gavi/Serena Vittorini
Continuing a Legacy of Saving Lives
And supporting future generations is exactly why we campaigned behind Gavi again this year. Global Citizens took over 385,000 actions to support Gavi’s 6.0 campaign, elevating the urgency of vaccine equity and pressuring donors to step up and support Gavi’s mission, including early pledges from the European Commission at Global Citizen Festival 2024, and from Croatia and Portugal at Global Citizen NOW 2025.
This year’s replenishment summit — co-hosted by the European Union and the Gates Foundation with production support from Global Citizen — secured commitments from 55 countries and other donors. Amidst a tough fundraising environment and rising pressure on foreign aid budgets worldwide, these donors reaffirmed their commitment to Gavi’s mission by collectively pledging more than $9 billion to support its next five-year strategic period through 2030. Though shy of the $11.9 billion goal at the outset of the campaign, it’s a significant step forward in helping make the world safer, healthier, and more equitable for all.
The United Kingdom, Gavi’s largest donor, pledged £1.25 billion ($1.7 billion) to support childhood immunization over the next five years. This pledge signals the country’s ongoing, continued leadership in global health. Meanwhile, the Gates Foundation committed another monumental pledge of $1.6 billion, matching its 2020-2025 pledge.
The European Union and its member states pledged more than a combined €2 billion ($2.33 billion), with the Commission itself contributing €360 million, sending a clear signal that Europe prioritizes global health. France committed €500 million, Germany pledged €600 million for the coming 5-year period, and Italy made a significant pledge of €250 million. Spain increased its contribution by over 25%, pledging $140 million, while Portugal boosted its contribution from the last cycle by 54% with a new €2.5 million pledge and Greece decided to step up with a €5 million commitment to Gavi’s cause.
Korea also went to bat for Gavi with a sizable $50 million commitment. Denmark, Ireland, Rwanda, and Uganda also made meaningful pledges to support Gavi’s work in vaccine access and strengthening health systems. In a major milestone, Indonesia — a former Gavi-supported country — joined as a first-time donor, pledging $30 million earlier in the campaign and paying forward the support it once received from the Alliance.
A few more significant pledges:
- Australia: Hon. Dr. Anne Aly, Minister of International Development, announced a AUD $386 million commitment — a 29% increase over its last pledge.
- Canada: Pledged CAD $675 million, marking a 12.5% increase from a commitment made just earlier this year in March.
- Croatia: Prime Minister Andrej Plenković initially announced the country’s first-ever commitment to Gavi of €1 million announced at Global Citizen NOW earlier this year, but decided at the replenishment event to increase their pledge to €6 million.
Pledges at the summit also unlocked $4.5 billion from major development finance institutions, along with up to $200 million in savings for Gavi-supported programs announced by private sector vaccine manufacturers. Other catalytic investments included $40 million to launch a new Innovation Scale-Up Fund, designed to fast-track solutions that strengthen immunization programs in hard-to-reach areas of the world.
We’ve seen that when Global Citizens raise their voices, world leaders listen. And when that happens, millions of lives can be changed. Together, these commitments represent more than just financial support — they reflect a global belief in the importance of health equity, pandemic preparedness, and that every child, everywhere, deserves a healthy life.
A Generational Opportunity
Nurses at HOPE Clinic Lukuli head out to the field for the weekly routine immunization outreach in Makindye Division, Kampala, Uganda in March 2024. Outreaches help in increasing immunization up-to-date rates in urban settings.
Vaccines are one of humanity’s most powerful tools. They protect lives, bolster economies, and protect the future.
Gavi’s model is built on innovation, partnership, and sustainability — support that has the potential to empower countries and communities for years and generations to come.
As Gavi enters its next chapter, we have the chance to protect more children from more diseases, shield the world from future pandemics, and help communities withstand the pressures of conflict, climate change, and inequality.
We can’t let this moment pass. Join us in calling on governments to step up at the Gavi Global Summit. Help ensure that no child is left behind—no matter where they’re born.
Take action now to urge the UK and other leaders to step up. Together, we can build a safer, stronger, and more prosperous world. For all.